Richter Transformation in the Brain from Chronic Lymphocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Richter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease.
r ichter syndrome is a clinical condition in which indolent chronic lymphocytic leukemia evolves into a more aggressive diffuse large B cell lymphoma. Maurice Nethaniel Richter first described this phenomenon in 1928, which was named the “Richter syndrome” in 1964 [1]. Due to the aggressive nature of the disorder, the clinical manifestations, prognosis and treatment differ from CLL1 [2]. Sympto...
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CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the molecule is not merely a prognostic marker but also a key element in the pathogenetic network underlying the disease. CD38 has a genetic polymorphism, characterized by a C>G variation in the regulatory region of intron 1. The working hypothesis is that the presence of different alleles in CLL patie...
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1Department of Genetics, Biology, and Biochemistry, 2Research Center for Experimental Medicine (CeRMS), University of Torino Medical School, Turin; 3Division of Hematology, Department of Clinical and Experimental Medicine & Biotechnologie Ricerca Medica Applicate (BRMA), Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara; 4Department of Medicine and Experi...
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Richter syndrome (RS) derives from the rare transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly of the diffuse large B cell lymphoma (DLBCL) type. The molecular pathogenesis of RS is only partially understood. By combining whole-exome sequencing and copy-number analysis of 9 CLL-RS pairs and of an extended panel of 43 RS cases, we show that this aggre...
متن کاملRichter transformation of chronic lymphocytic leukemia presenting as a dural-based non-hodgkin lymphoma mass.
Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL). We present a 64-year-old man with a history of CLL and a left parieto-occipital transtentorial extra-axial mass. The patient underwent CT and MR imaging, demonstrating a large dural-based mass with extracranial extension, which occluded the left transverse sinus...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hematopathology
سال: 2013
ISSN: 1346-4280,1880-9952
DOI: 10.3960/jslrt.53.157